Inside every human cell, six feet of DNA folds into a nucleus that is only a few micrometers wide, yet still manages to ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes.

When DNA breaks, cells must repair it accurately to prevent harmful mutations. Researchers have discovered that during a key ...

High-resolution imaging has revealed the internal layout of chromatin condensates, showing how DNA fibers fold and interact ...

Fluorogenic DNA aptamers produce light only in the correct structural state, enabling programmable molecular logic, ...

Cancer isn't just about broken genes—it's about broken architecture. Imagine a city where roads suddenly vanish, cutting off ...

MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

In the middle of the 20th century, accumulating data suggested that DNA carries life’s genetic information. Biochemists around the world raced to determine its structure. The competition led to some ...

Colibactin is a powerful toxin produced by Escherichia coli and other bacteria living in the human gut. This highly unstable ...

A closeup look at colibactin’s structure reveals chemical motifs that guide its mutation-wreaking “warheads” to specific stretches of DNA.